Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal

Summary: Chemotaxis and lysosomal function are closely intertwined processes essential for the inflammatory response and clearance of intracellular bacteria. We used the zebrafish model to examine the link between chemotactic signaling and lysosome physiology in macrophages during mycobacterial infe...

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Hauptverfasser:	Frida Sommer, Vincenzo Torraca, Yufei Xie, Aliede E. in ‘t Veld, Joost Willemse, Annemarie H. Meijer
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-04-01
Schriftenreihe:	Cell Reports
Schlagworte:	macrophage chemotaxis lysosome vesicle zebrafish mycobacteria
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124721003144
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