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NR4A1 Promotes Diabetic Nephropathy by Activating Mff-Mediated Mitochondrial Fission and Suppressing Parkin-Mediated Mitophagy

Background/Aims: Disrupted mitochondrial dynamics, including excessive mitochondrial fission and mitophagy arrest, has been identified as a pathogenic factor in diabetic nephropathy (DN), although the upstream regulatory signal for mitochondrial fission activation and mitophagy arrest in the setting...

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Principais autores: Junqin Sheng, Hongyan Li, Qin Dai, Chang Lu, Min Xu, Jisheng Zhang, Jianxun Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
coleção:Cellular Physiology and Biochemistry
Assuntos:
Mff
NR4A1
Parkin
Mitochondrial fission
Mitophagy
Diabetic renal damage
Acesso em linha:https://www.karger.com/Article/FullText/492292
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