Multi-omics profiling implicates gut microbiota-sphingolipid interplay in the neuroprotective effects of semaglutide on diabetic cognitive impairment

BackgroundThe gut microbiome is a critical regulator of host health, but how it mediates the therapeutic effects of drugs targeting neurodegenerative diseases like diabetic cognitive impairment (DCI) is unclear. Here, we investigated whether the neuroprotective effects of the GLP-1 agonist semagluti...

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Autori principali:	Liqin Qi, Huimin Kang, Xiaofen Li, Lijing Wang, Yinchen Lin, Menglan Zhan, Feihui Zeng, Zhiwen Xiao, Xiaoying Liu, Zhou Chen, Libin Liu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Microbiology
Soggetti:	diabetic encephalopathy semaglutide gut microbiota sphingolipid metabolism bile acids
Accesso online:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1705784/full
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