Self-assembled angiopep-2 modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles delivery TMZ for glioma synergistic TMZ and RT therapy

The addition of temozolomide (TMZ) to radiotherapy (RT) improves survival of patients with glioblastoma (GBM). However, TMZ + RT causes excess toxicity in patients. In this study, we prepared angiopep-2 (A2) modified lipid-poly (hypoxic radiosensitized polyprodrug) nanoparticles for TMZ delivery (A2...

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Detalhes bibliográficos

Principais autores:	Zhenkun Zong, Lei Hua, Zhen Wang, Haoyue Xu, Chengkun Ye, Bomin Pan, Zongren Zhao, Longzhen Zhang, Jun Lu, Hongmei Liu, Rutong Yu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2019-01-01
coleção:	Drug Delivery
Assuntos:	glioma angiopep-2 radiosensitized polyprodrug tmz synergetic therapy
Acesso em linha:	http://dx.doi.org/10.1080/10717544.2018.1534897
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