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5-aza-2′-deoxycytidine Inhibits the Proliferation of Lung Fibroblasts in Neonatal Rats Exposed to Hyperoxia

A persistent increase in the number of lung fibroblasts (LFs) is found in the interstitium of the lungs of infants with bronchopulmonary dysplasia (BPD), which leads to lung fibrosis. P16 methylation plays an important role in the pathogenesis of BPD. 5-aza-2′-deoxycytidine (5-aza-CdR) is a major me...

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Principais autores: Shimeng Zhao, Meiling Cao, Hongmin Wu, Yu Hu, Xindong Xue
פורמט: Artigo
שפה:Inglês
יצא לאור: Elsevier 2017-04-01
סדרה:Pediatrics and Neonatology
נושאים:
bronchopulmonary dysplasia
lung interstitial fibrosis
P16 gene
5-aza-2′-deoxycytidine
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S1875957216300420
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