Lower plasma PCSK9 in normocholesterolemic subjects is associated with upregulated adipose tissue surface‐expression of LDLR and CD36 and NLRP3 inflammasome

Abstract Background LDL‐cholesterol lowering variants that upregulate receptor uptake of LDL, such as in PCSK9 and HMGCR, are associated with diabetes via unclear mechanisms. Activation of the NLRP3 inflammasome/interleukin‐1 beta (IL‐1β) pathway promotes white adipose tissue (WAT) dysfunction and t...

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Autors principals:	Yannick Cyr, Valérie Lamantia, Simon Bissonnette, Melanie Burnette, Aurèle Besse‐Patin, Annie Demers, Martin Wabitsch, Michel Chrétien, Gaétan Mayer, Jennifer L. Estall, Maya Saleh, May Faraj
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2021-02-01
Col·lecció:	Physiological Reports
Matèries:	adipose tissue and systemic inflammation apoB‐lipoproteins cardiometabolic risk plasma apoB‐to‐PCSK9
Accés en línia:	https://doi.org/10.14814/phy2.14721
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