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Imaging of glucose metabolism by 13C-MRI distinguishes pancreatic cancer subtypes in mice

Metabolic differences among and within tumors can be an important determinant in cancer treatment outcome. However, methods for determining these differences non-invasively in vivo is lacking. Using pancreatic ductal adenocarcinoma as a model, we demonstrate that tumor xenografts with a similar gene...

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Autori principali: Shun Kishimoto, Jeffrey R Brender, Daniel R Crooks, Shingo Matsumoto, Tomohiro Seki, Nobu Oshima, Hellmut Merkle, Penghui Lin, Galen Reed, Albert P Chen, Jan Henrik Ardenkjaer-Larsen, Jeeva Munasinghe, Keita Saito, Kazutoshi Yamamoto, Peter L Choyke, James Mitchell, Andrew N Lane, Teresa WM Fan, W Marston Linehan, Murali C Krishna
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications Ltd 2019-08-01
Serie:eLife
Soggetti:
imaging
MRI
metabolism
metabolomics
tumor microenvironment
magnetic resonance spectroscopy
Accesso online:https://elifesciences.org/articles/46312
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