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Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross-stage recognition of glutamate-rich repeats

Circulating sexual stages of Plasmodium falciparum (Pf) can be transmitted from humans to mosquitoes, thereby furthering the spread of malaria in the population. It is well established that antibodies can efficiently block parasite transmission. In search for naturally acquired antibodies targets on...

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Principais autores: Axelle Amen, Randy Yoo, Amanda Fabra-García, Judith Bolscher, William JR Stone, Isabelle Bally, Sebastián Dergan-Dylon, Iga Kucharska, Roos M de Jong, Marloes de Bruijni, Teun Bousema, C Richter King, Randall S MacGill, Robert W Sauerwein, Jean-Philippe Julien, Pascal Poignard, Matthijs M Jore
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2025-01-01
coleção:eLife
Assuntos:
gametocytes
gametes
monoclonal antibody
repeat motif
homotypic interactions
transmission-blocking
Acesso em linha:https://elifesciences.org/articles/97865
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