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Glutamine synthetase modulates YAP activation by stabilizing LATS under glutamine homeostasis

Summary: Glutamine homeostasis plays a crucial role in fundamental cellular processes and is often dysregulated in cancer cells; however, the underlying mechanisms governing this homeostasis remain unclear. Here, we demonstrate that enriched glutamine activates the Hippo pathway. Mechanistically, gl...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Siyi Li, Ting Ling, Yuhan Wang, Jing Shi, Qiuping Wang, Jing Lv, Jinghan Li, Yu Liu, Yi Zhang, Changhao Liu, Tian Xia, Di Chen, Wenqi Wang, Hong-Xu Liu, Hai-long Piao
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2025-12-01
Rangatū:Cell Reports
Ngā marau:
CP: cancer
CP: metabolism
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124725013920
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