Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.

Matriptase, a membrane-associated serine protease, plays an essential role in epidermal barrier function through activation of the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin. The matriptase-prostasin proteolytic cascade is tightly regulated by hepatocyte growth factor acti...

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Autori principali:	Ya-Wen Chen, Zhenghong Xu, Adrienne N H Baksh, Jehng-Kang Wang, Chiu-Yuan Chen, Richard Swanson, Steve T Olson, Hiroaki Kataoka, Michael D Johnson, Chen-Yong Lin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Public Library of Science (PLoS) 2013-01-01
Serie:	PLoS ONE
Accesso online:	https://doi.org/10.1371/journal.pone.0062826
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