A GSTP1-mediated lactic acid signaling promotes tumorigenesis through the PPP oxidative branch

Abstract Lactic acidosis is a feature of solid tumors and plays fundamental role(s) rendering cancer cells to adapt to diverse metabolic stresses, but the mechanism underlying its roles in redox homeostasis remains elusive. Here we show that G6PD is phosphorylated at tyrosine 249/322 by the SRC thro...

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Manylion Llyfryddiaeth

Prif Awduron:	Yandi Sun, Qian He, Jingjia Li, Ze Yang, Mashaal Ahmad, Yindan Lin, Di Wu, Lei Zheng, Jiangtao Li, Ben Wang, Chitty Chen, Yue Hu, Heng Luo, Yan Luo
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Nature Publishing Group 2023-07-01
Cyfres:	Cell Death and Disease
Mynediad Ar-lein:	https://doi.org/10.1038/s41419-023-05998-4
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!