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Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults

Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster vaccination, they produced fewer spike-specific circulating fol...

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Principais autores: Kohei Kometani, Takaaki Yorimitsu, Norihide Jo, Erina Yamaguchi, Osamu Kikuchi, Masaru Fukahori, Takeshi Sawada, Yoshitaka Tsujimoto, Ayana Sunami, Mengqian Li, Takeshi Ito, Yann Pretemer, Yuxian Gao, Yu Hidaka, Masaki Yamamoto, Natsuko Kaku, Yu Nakagama, Yasutoshi Kido, Alba Grifoni, Alessandro Sette, Miki Nagao, Satoshi Morita, Takako E. Nakajima, Manabu Muto, Yoko Hamazaki
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-12-01
coleção:Frontiers in Immunology
Assuntos:
immunological memory
mRNA vaccine
immune aging
memory T cells
memory B cells
cTfh
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1455334/full
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