Structure-guided identification of small molecules potentially able to modulate GDF15 activity

Abstract Growth Differentiation Factor 15 (GDF15) has been associated with different pathological conditions, including cancer cachexia. Various strategies, such as monoclonal antibodies and peptide antagonists, have been developed to inhibit GDF15 activity; however, it is currently unknown whether...

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Principais autores:	Antonio Chiariello, Lorenzo Lenti, Lorenzo Trofarello, Manuela Sollazzo, Mattia Lauriola, Alberto Del Rio, Stefano Salvioli, Marco Daniele Parenti, Maria Conte
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-05-01
Series:	Scientific Reports
Assuntos:	GDF15 Small organic molecules Virtual screening Ovarian cancer cells
Acceso en liña:	https://doi.org/10.1038/s41598-026-51932-x
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