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Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Abstract Lactylation is a novel post‐translational modification closely related to the glycolytic process, but the regulatory mechanisms between lactylation and glycolysis are far from being elucidated. Lactate dehydrogenase A (LDHA) catalyzes the formation of lactate, which provides the modifying g...

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Principais autores: Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-01-01
Serier:Advanced Science
Fag:
DNA damage repair
glycolysis
lactylation
LDHA
Online adgang:https://doi.org/10.1002/advs.202510733
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