Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops

Antibodies are critical components of adaptive immunity, binding with high affinity to pathogenic epitopes. Antibodies undergo rigorous selection to achieve this high affinity, yet some maintain an additional basal level of low affinity, broad reactivity to diverse epitopes, a phenomenon termed ‘pol...

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Detalhes bibliográficos

Principais autores:	Christopher T Boughter, Marta T Borowska, Jenna J Guthmiller, Albert Bendelac, Patrick C Wilson, Benoit Roux, Erin J Adams
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2020-11-01
coleção:	eLife
Assuntos:	biophysics antibody specificity information theory machine learning bioinformatics immunology
Acesso em linha:	https://elifesciences.org/articles/61393
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