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EPIREGULIN creates a developmental niche for spatially organized human intestinal enteroids

Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development. Here, we interrogated the cell signaling environment within the developing human intestine to...

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Principais autores: Charlie J. Childs, Emily M. Holloway, Caden W. Sweet, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie, Madeline K. Eiken, Meghan M. Capeling, Rachel K. Zwick, Brisa Palikuqi, Coralie Trentesaux, Joshua H. Wu, Oscar Pellón-Cardenas, Charles J. Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, J. Gray Camp, Jonathan Z. Sexton, Ophir D. Klein, Michael P. Verzi, Jason R. Spence
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2023-03-01
Serier:JCI Insight
Fag:
Development
Stem cells
Online adgang:https://doi.org/10.1172/jci.insight.165566
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