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Phosphoenolpyruvate carboxylase (PEPC) is essential for the glycolytic pathway and parasite proliferation in Babesia gibsoni

Abstract Apicomplexan parasites predominantly generate ATP and lactic acid through glycolysis and anaerobic glucose metabolism, incorporating CO2 into glycolysis via a stage-dependent phosphoenolpyruvate carboxylase (PEPC) mechanism. Although the role of PEPC in plant and bacterial carbon fixation i...

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Principais autores: Dong-Fang Li, Ling-Na Wang, Yi-Dan Bai, Yu-Xin Yu, Xing Lu, Xing-Ai Guan, Fang-Jie Li, Sen Wang, Lan He, Jun-Long Zhao
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-12-01
Serier:Animal Diseases
Fag:
Babesia gibsoni
Phosphoenolpyruvate
Phosphoenolpyruvate carboxylase
Malate
Aspartate
Online adgang:https://doi.org/10.1186/s44149-024-00148-5
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