Novel Flow Cytometric Immunoassay for Detection of Proinsulin Autoantibodies in Diabetes Mellitus Employing a Recombinant Autoantigen Expressed in E. coli

IntroductionInsulin and proinsulin autoantibodies (IAA/PAA) are usually the first markers to appear in patients with type 1 Diabetes Mellitus (T1DM) and their prevalence ranges from 10 to 60% in the child-adolescent population. The reference method for IAA/PAA detection is the Radioligand Binding As...

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Bibliografische Detailangaben

Hauptverfasser:	Adriana Victoria Sabljic, Silvina Sonia Bombicino, Juan Ignacio Marfía, Luciano Lucas Guerra, Alberto Penas Steinhardt, Natalia Inés Faccinetti, Rubén Francisco Iacono, Edgardo Poskus, Aldana Trabucchi, Silvina Noemí Valdez
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-04-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	diabetes mellitus autoimmunity autoantibodies proinsulin flow cytometry immunoassay
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.648021/full
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