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A multiscale approach to characterize the early aggregation steps of the amyloid-forming peptide GNNQQNY from the yeast prion sup-35.

The self-organization of peptides into amyloidogenic oligomers is one of the key events for a wide range of molecular and degenerative diseases. Atomic-resolution characterization of the mechanisms responsible for the aggregation process and the resulting structures is thus a necessary step to impro...

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Principais autores: Jessica Nasica-Labouze, Massimiliano Meli, Philippe Derreumaux, Giorgio Colombo, Normand Mousseau
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2011-05-01
סדרה:PLoS Computational Biology
גישה מקוונת:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21625573/?tool=EBI
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