PKMζ alters oxycodone-taking in a dose- and sex-dependent manner

Opioid use disorder involves disruptions to glutamate homeostasis and dendritic spine density in the reward system. PKMζ is an atypical isoform of protein kinase C that is expressed exclusively in neurons and plays a role in postsynaptic glutamate signaling and dendritic spine maturation. As opioid...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Melissa C. Knouse, Alyssa R. Kniffin, Erin A. English, William Cuadrado, Troy M. Houser, Lisa A. Briand
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Elsevier 2024-09-01
Serie:	Addiction Neuroscience
Ämnen:	Addiction Oxycodone PKMζ Sex differences Self-administration Motivation
Länkar:	http://www.sciencedirect.com/science/article/pii/S2772392524000282
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!