GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation
Abstract The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology. Inherited pathogenic GFI1B variants result in thrombocytopenia and bleeding propensities with vary...
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| Hoofdauteurs: | , , , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
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Nature Portfolio
2024-03-01
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| Reeks: | Communications Biology |
| Online toegang: | https://doi.org/10.1038/s42003-024-06090-z |
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