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Second-Line Therapies in Primary Biliary Cholangitis: A Comparative Review of Obeticholic Acid, Fibrates, Seladelpar, and Elafibranor

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease marked by cholestasis and progressive fibrosis. While ursodeoxycholic acid (UDCA) remains the first-line therapy, approximately 30–40% of patients have an inadequate biochemical response, increasing the risk of disease progressi...

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Principais autores: Fares Jamal, Amani Elshaer, Mayar H. Alatout, Nour B. Odeh, Amal Youssef, Humam Abo Abdullah, Sandra Elmasry, Tala Shahin, Hussein Abdul Nabi, Astin R. Worden, Talha A. Malik, Blanca C. Lizaola-Mayo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-09-01
Serier:Biomedicines
Fag:
primary biliary cholangitis
second-line therapy
obeticholic acid
fenofibrate
seladelpar
elafibranor
Online adgang:https://www.mdpi.com/2227-9059/13/10/2335
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