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Proteasome inhibitor bortezomib prevents proliferation and migration of pulmonary arterial smooth muscle cells

Abstract Pulmonary vascular remodeling is a key pathological process of pulmonary arterial hypertension (PAH), characterized by uncontrolled proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). Bortezomib (BTZ) is the first Food and Drug Administration (FDA)‐approved prote...

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Principais autores: Yi‐Ching Liu, Yu‐Hsin Tseng, Yu‐Hsin Kuan, Lin‐Yen Wang, Shang‐En Huang, Siao‐Ping Tsai, Jwu‐Lai Yeh, Jong‐Hau Hsu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2024-06-01
Serier:Kaohsiung Journal of Medical Sciences
Fag:
bortezomib
migration
proliferation
pulmonary arterial hypertension
Online adgang:https://doi.org/10.1002/kjm2.12835
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