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NK Cell Alloreactivity against KIR-Ligand-Mismatched HLA-Haploidentical Tissue Derived from HLA Haplotype-Homozygous iPSCs

HLA haplotype-homozygous (HLA-homo) induced pluripotent stem cells (iPSCs) are being prepared to be used for allogeneic transplantation of regenerated tissue into recipients carrying an identical haplotype in one of the alleles (HLA-hetero). However, it remains unaddressed whether natural killer (NK...

Celý popis

Uloženo v:
Hlavní autoři: Hiroshi Ichise, Seiji Nagano, Takuya Maeda, Masaki Miyazaki, Yuki Miyazaki, Hiroto Kojima, Nobuyo Yawata, Makoto Yawata, Hidenori Tanaka, Hiroh Saji, Kyoko Masuda, Hiroshi Kawamoto
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017-09-01
Edice:Stem Cell Reports
Témata:
iPSCs
NK cells
KIR
KIR ligand
HLA-C
transplantation
regeneration
vascular endothelial cells
HLA haplotype-homozygote
missing-self recognition
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213671117303302
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