15-lipoxygenase blockade switches off pan-organ ischaemia-reperfusion injury by inhibiting pyroptosis

Abstract Even with reperfusion therapy, ischemia-reperfusion (I/R) injury remains to be a major driver of organ failure associated with myocardial infarction, stroke, and liver transplantation, with effective therapeutic targets still elusive. Using in vitro hypoxia/reoxygenation (H/R) models, we di...

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Prif Awduron:	Jie Li, Hailong Zhang, Mengmeng Dai, Yongpan Huang
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Springer 2025-10-01
Cyfres:	Molecular Biomedicine
Pynciau:	ALOX15 15-HpETE Thiolox Lipid peroxidation Inflammasome Pyroptosis
Mynediad Ar-lein:	https://doi.org/10.1186/s43556-025-00325-z
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!