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Hexokinase 2-mediated glycolysis supports inflammatory responses to Porphyromonas gingivalis in gingival fibroblasts

Abstract Background When infected with Porphyromonas gingivalis, gingival fibroblasts undergo metabolic reprogramming, and rely on aerobic glycolysis rather than oxidative phosphorylation for rapid energy replenishment. Hexokinases (HKs) are catalysts for glucose metabolism, and HK2 constitutes the...

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Principais autores: Wenqi Su, Jingwen Li, Lishan Jiang, Lang Lei, Houxuan Li
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-02-01
Serier:BMC Oral Health
Fag:
Hexokinase 2
Gingival fibroblasts
Porphyromonas gingivalis
Glycolysis
Periodontitis
Online adgang:https://doi.org/10.1186/s12903-023-02807-4
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