A novel phosphodiesterase target as a therapeutic approach: inhibiting DEN-induced hepatocellular carcinoma progression

Hepatocellular Carcinoma (HCC) is one of the most common and fatal types of liver cancer worldwide; in this sense, Diethylnitrosamine (DEN) has been established as a potent carcinogen affecting the development and progression of this disease. The present work focused on determining whether phosphodi...

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Hauptverfasser:	Anil Kumar, Dharmendra Singh Rajput, Mandeep Kumar Gupta, Vivek Kumar, Harpreet Singh, Arun Kumar Mishra, Shivani Chopra, Hitesh Chopra
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2025-03-01
Schriftenreihe:	EXCLI Journal : Experimental and Clinical Sciences
Schlagworte:	HCC diethylnitrosamine (DEN) phosphodiesterase (PDE) inhibitors PDE5 cGMP-PKG pathway JNK pathwaytherapy
Online-Zugang:	https://www.excli.de/excli/article/view/7941
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