Cre/LoxP Genetic Recombination Sustains Cartilage Anabolic Factor Expression in Hyaluronan Encapsulated MSCs Alleviates Intervertebral Disc Degeneration

(1) Background: Inexplicable low back and neck pain frequently results from spinal disc degeneration with an imbalanced intervertebral disc (IVD) cell homeostasis. We hypothesize that introducing MSC expressing a sustained cartilage-anabolic factor in the IVD may stimulate the mucoid materials secre...

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Váldodahkkit:	Long-Yi Chan, Cheng-Chung Chang, Po-Liang Lai, Tomoji Maeda, Horng-Chaung Hsu, Chin-Yu Lin, Shu-Jui Kuo
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2022-02-01
Ráidu:	Biomedicines
Fáttát:	runx1 transcription factor baculoviral vector gene therapy Cre/LoxP gene editing disc degeneration
Liŋkkat:	https://www.mdpi.com/2227-9059/10/3/555
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