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Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are neurodegenerative disorders characterized by the misfolding and aggregation of alpha-synuclein (aSyn). Doxycycline, a tetracyclic antibiotic shows neuroprotective effects, initially proposed to be due to its anti-inflammatory propertie...

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Autores principales: Antonio Dominguez-Meijide, Valeria Parrales, Eftychia Vasili, Florencia González-Lizárraga, Annekatrin König, Diana F. Lázaro, Annie Lannuzel, Stéphane Haik, Elaine Del Bel, Rosana Chehín, Rita Raisman-Vozari, Patrick P. Michel, Nicolas Bizat, Tiago Fleming Outeiro
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2021-04-01
Colección:Neurobiology of Disease
Materias:
Alpha-synuclein
Parkinson's disease
Doxycycline
Aggregation
C. elegans
Acceso en línea:http://www.sciencedirect.com/science/article/pii/S096999612100005X
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