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A randomized, double-blind, placebo-controlled study of a GHSR blocker in people with alcohol use disorder

BACKGROUND Studies have demonstrated the role of ghrelin in alcohol-related behaviors and consumption. Blockade of the growth hormone secretagogue receptor (GHSR), which is the ghrelin receptor, has been shown to decrease alcohol drinking and reward-related behaviors across several animal models. We...

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Principais autores: Monica L. Faulkner, Mehdi Farokhnia, Mary R. Lee, Lisa Farinelli, Brittney D. Browning, Kelly Abshire, Allison M. Daurio, Vikas Munjal, Sara L. Deschaine, Selim R. Boukabara, Christopher Fortney, Garrick Sherman, Melanie Schwandt, Fatemeh Akhlaghi, Reza Momenan, Thomas J. Ross, Susan Persky, Lorenzo Leggio
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2024-12-01
Serier:JCI Insight
Fag:
Clinical trials
Online adgang:https://doi.org/10.1172/jci.insight.182331
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