Supramolecular Complexes of β-Cyclodextrin with Clomipramine and Doxepin: Effect of the Ring Substituent and Component of Drugs on Their Inclusion Topologies and Structural Flexibilities

Depression is a global threat. Tricyclic antidepressants (TCAs) are still efficacious in treating depression, albeit with more side effects. Cyclodextrins (CDs) with a suitable nanocavity are potential drug carriers and can enhance the drug bioavailability. Aiming for an atomistic understanding of t...

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Hlavní autor:	Thammarat Aree
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-09-01
Edice:	Pharmaceuticals
Témata:	β-cyclodextrin clomipramine doxepin tricyclic antidepressants X-ray analysis density functional theory (DFT) calculation
On-line přístup:	https://www.mdpi.com/1424-8247/13/10/278
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