PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

Summary: Delayed-type hypersensitivity (DTH) responses underpin chronic inflammation. Using a model of oxazolone-induced dermatitis and a combination of transgenic mice, adoptive cell transfer, and selective agonists/antagonists against protease activated receptors, we show that that PAR-1 signaling...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Hannah Wilkinson, Hugh Leonard, Daxin Chen, Toby Lawrence, Michael Robson, Pieter. Goossens, John H. McVey, Anthony Dorling
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-01-01
Schriftenreihe:	iScience
Schlagworte:	Molecular Biology Immunology
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2589004220311780
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!