Hemozoin-mediated inflammasome activation limits long-lived anti-malarial immunity

Summary: During acute malaria, most individuals mount robust inflammatory responses that limit parasite burden. However, long-lived sterilizing anti-malarial memory responses are not efficiently induced, even following repeated Plasmodium exposures. Using multiple Plasmodium species, genetically mod...

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Bibliografiske detaljer

Principais autores:	Angela D. Pack, Patrick V. Schwartzhoff, Zeb R. Zacharias, Daniel Fernandez-Ruiz, William R. Heath, Prajwal Gurung, Kevin L. Legge, Chris J. Janse, Noah S. Butler
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2021-08-01
Serier:	Cell Reports
Fag:	Plasmodium malaria hemozoin humoral immunity germinal center T follicular helper
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124721010202
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