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Mek1 and Mek2 Functional Redundancy in Erythropoiesis

Several studies have established the crucial role of the extracellular signal–regulated kinase (ERK)/mitogen-activated protein kinase pathway in hematopoietic cell proliferation and differentiation. MEK1 and MEK2 phosphorylate and activate ERK1 and ERK2. However, whether MEK1 and MEK2 differentially...

Celý popis

Uloženo v:
Hlavní autoři: Laurent Beuret, Simon-Pierre Fortier-Beaulieu, Vincent Rondeau, Sophie Roy, Nicolas Houde, Karl Balabanian, Marion Espéli, Jean Charron
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021-07-01
Edice:Frontiers in Cell and Developmental Biology
Témata:
ERK/MAP kinase pathway
Mek genes
hematopoiesis
erythropoiesis
gene inactivation
On-line přístup:https://www.frontiersin.org/articles/10.3389/fcell.2021.639022/full
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