Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formatio...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2017-09-01
Schriftenreihe:	eLife
Schlagworte:	hinokiflavone RNA splicing SUMO SENP1 U2 snRNP
Online-Zugang:	https://elifesciences.org/articles/27402
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