The Experimental TASK-1 Potassium Channel Inhibitor A293 Can Be Employed for Rhythm Control of Persistent Atrial Fibrillation in a Translational Large Animal Model

BackgroundUpregulation of the two-pore-domain potassium channel TASK-1 (hK2P3.1) was recently described in patients suffering from atrial fibrillation (AF) and resulted in shortening of the atrial action potential. In the human heart, TASK-1 channels facilitate repolarization and are specifically ex...

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Principais autores:	Felix Wiedmann, Christoph Beyersdorf, Xiao-Bo Zhou, Manuel Kraft, Kathrin I. Foerster, Ibrahim El-Battrawy, Siegfried Lang, Martin Borggrefe, Walter E. Haefeli, Norbert Frey, Constanze Schmidt
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2021-01-01
סדרה:	Frontiers in Physiology
נושאים:	A293 antiarrhythmic pharmacotherapy atrial fibrillation cardioversion KCNK3 TASK-1
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fphys.2020.629421/full
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