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Hematopoietic differentiation persists in human iPSCs defective in de novo DNA methylation

Abstract Background DNA methylation is involved in the epigenetic regulation of gene expression during developmental processes and is primarily established by the DNA methyltransferase 3A (DNMT3A) and 3B (DNMT3B). DNMT3A is one of the most frequently mutated genes in clonal hematopoiesis and leukemi...

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Principais autores: Olivia Cypris, Julia Franzen, Joana Frobel, Philipp Glück, Chao-Chung Kuo, Stephani Schmitz, Selina Nüchtern, Martin Zenke, Wolfgang Wagner
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-06-01
Serier:BMC Biology
Fag:
DNMT3A
Epigenetics
DNA methylation
CRISPR/Cas9
Induced pluripotent stem cells
Mesenchymal differentiation
Online adgang:https://doi.org/10.1186/s12915-022-01343-x
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