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New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.

Class II Fructose-1,6-bisphosphatases (FBPaseII) (EC: 3.1.3.11) are highly conserved essential enzymes in the gluconeogenic pathway of microorganisms. Previous crystallographic studies of FBPasesII provided insights into various inactivated states of the enzyme in different species. Presented here i...

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Autors principals: Anna I Selezneva, Luke N M Harding, Hiten J Gutka, Farahnaz Movahedzadeh, Celerino Abad-Zapatero
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2023-01-01
Col·lecció:PLoS ONE
Accés en línia:https://doi.org/10.1371/journal.pone.0274723
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