Reactive oxygen species reprogram macrophages to suppress antitumor immune response through the exosomal miR-155-5p/PD-L1 pathway

Abstract Background Cancer cells have an imbalance in oxidation-reduction (redox) homeostasis. Understanding the precise mechanisms and the impact of the altered redox microenvironment on the immunologic reaction to tumors is limited. Methods We isolated exosomes from ovarian cancer cells through ul...

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Principais autores:	Xiang Li, Shaomin Wang, Wei Mu, Jennifer Barry, Anna Han, Richard L. Carpenter, Bing-Hua Jiang, Stephen C. Peiper, Mỹ G. Mahoney, Andrew E. Aplin, Hong Ren, Jun He
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2022-01-01
Series:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Reactive oxygen species Tumor immune response Ovarian cancer Tumor-associated macrophages Tumor exosomes miR-155-5p
Acceso en liña:	https://doi.org/10.1186/s13046-022-02244-1
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