Pharyngeal Pumping and Tissue-Specific Transgenic P-Glycoprotein Expression Influence Macrocyclic Lactone Susceptibility in <i>Caenorhabditis elegans</i>

Macrocyclic lactones (MLs) are widely used drugs to treat and prevent parasitic nematode infections. In many nematode species including a major pathogen of foals, <i>Parascaris univalens</i>, resistance against MLs is widespread, but the underlying resistance mechanisms and ML penetration routes int...

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Bibliografische Detailangaben

Hauptverfasser:	Alexander P. Gerhard, Jürgen Krücken, Cedric Neveu, Claude L. Charvet, Abdallah Harmache, Georg von Samson-Himmelstjerna
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-02-01
Schriftenreihe:	Pharmaceuticals
Schlagworte:	macrocyclic lactones nematode parasitology P-glycoprotein drug resistance
Online-Zugang:	https://www.mdpi.com/1424-8247/14/2/153
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