Resistance mechanisms for Gram-negative bacteria-specific lipopeptides, turnercyclamycins, differ from that of colistin

ABSTRACT Turnercyclamycin A and B lipopeptides exhibit Gram-negative bacteria-specific toxicity. This includes CDC urgent threat organisms such as multidrug-resistant Acinetobacter baumannii. Like the last-line agent colistin, turnercyclamycins interact with the lipopolysaccharide (LPS) pathway, but...

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Autors principals:	Albebson L. Lim, Bailey W. Miller, Zhenjian Lin, Mark A. Fisher, Louis R. Barrows, Margo G. Haygood, Eric W. Schmidt
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2023-12-01
Col·lecció:	Microbiology Spectrum
Matèries:	lipopeptides antibiotics Gram-negative bacteria Acinetobacter colistin drug resistance
Accés en línia:	https://journals.asm.org/doi/10.1128/spectrum.02306-23
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