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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

The proinflammatory alarmins S100A8 and S100A9 are among the most abundant proteins in neutrophils and monocytes but are completely silenced after differentiation to macrophages. The molecular mechanisms of the extraordinarily dynamic transcriptional regulation of S100a8 and S100a9 genes, however, a...

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Principais autores: Saskia-Larissa Jauch-Speer, Marisol Herrera-Rivero, Nadine Ludwig, Bruna Caroline Véras De Carvalho, Leonie Martens, Jonas Wolf, Achmet Imam Chasan, Anika Witten, Birgit Markus, Bernhard Schieffer, Thomas Vogl, Jan Rossaint, Monika Stoll, Johannes Roth, Olesja Fehler
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2022-05-01
coleção:eLife
Assuntos:
C/EBPδ
calprotectin
CRISPR/Cas9 screen
monocytes
S100A8/A9
human
Acesso em linha:https://elifesciences.org/articles/75594
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