Integrated genomic-transcriptomic analysis of clavulanic acid production in differentially productive Streptomyces clavuligerus strains

Abstract Clavulanic acid (CA) is a specific metabolite that inhibits β-lactamases, which inactivate β-lactam antibiotics, therefore reinstating the activity of β-lactams against β-lactamase-producing pathogens, and surmounting β-lactam resistance. While extensive efforts have been made to optimize C...

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Hauptverfasser:	Junpyo Gong, Jeong Sang Yi, Seungchan An, Hang Su Cho, Chang Hun Shin, Hyung-Jin Won, Namil Lee, Yongjae Lee, Byung-Kwan Cho, Minsoo Noh, Yeo Joon Yoon
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2025-11-01
Schriftenreihe:	Scientific Reports
Online-Zugang:	https://doi.org/10.1038/s41598-025-29509-x
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