Genome-wide investigation of synthetic rescue interactions in Alzheimer’s disease implicates glial lipid and sterol metabolism

Abstract Background Synthetic rescue (SR) interactions, where a disease-promoting alteration in one gene is compensated by a secondary alteration in another gene, remain largely unexplored in Alzheimer’s disease (AD). Here, we performed a genome-wide investigation of SR gene pairs that mitigate the...

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Hlavní autoři:	Jun Ki Yoo, Ju Han Kim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-04-01
Edice:	Alzheimer’s Research & Therapy
Témata:	Alzheimer’s disease Synthetic rescue Genetic interaction Whole exome sequencing Cognitive resilience Lipid metabolism
On-line přístup:	https://doi.org/10.1186/s13195-026-02009-4
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