Design and Synthesis of Marine-Inspired Itampolin A Derivatives to Overcome Chemoresistance in NSCLC via Cholesterol Homeostasis Modulation

Recent studies on brominated tyrosine-derived marine natural products have significantly expanded the library of known structures and revealed their potent and diverse antitumor mechanisms. Building upon our previous research on the natural product itampolin A isolated from marine sponges, we conduc...

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Main Authors: Hai-Ying Zhang, Shun-Chang Ji, Si-Hua Xie, Yu Chen, Cai-Xia Lin, Xu Huang, Yi-Qiao Wang, Jing-Wei Liang, Yan Liu
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-09-01
Colecção:Marine Drugs
Assuntos:
non-small cell lung cancer
drug-resistant
MAPK pathway
cholesterol
bioinformatic
Acesso em linha:https://www.mdpi.com/1660-3397/23/9/357
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