Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice

Beta cell dysfunction and reduction in beta cell mass are hallmark events in the pathogenesis of diabetes mellitus. We identify focal adhesion protein Kindlin-2 as a key factor that controls insulin synthesis and secretion and beta cell mass by modulating MafA and beta-catenin proteins in pancreatic...

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Bibliografiske detaljer

Principais autores:	Ke Zhu, Yumei Lai, Huiling Cao, Xiaochun Bai, Chuanju Liu, Qinnan Yan, Liting Ma, Di Chen, Giedrius Kanaporis, Junqi Wang, Luyuan Li, Tao Cheng, Yong Wang, Chuanyue Wu, Guozhi Xiao
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2020-01-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-019-14186-y
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