An Adaptable Physiological Model of Endocytic Megalin Trafficking in Opossum Kidney Cells and Mouse Kidney Proximal Tubule

Abstract The cells that comprise the proximal tubule (PT) are specialized for high-capacity apical endocytosis necessary to maintain a protein-free urine. Filtered proteins are reclaimed via receptor-mediated endocytosis facilitated by the multiligand receptors megalin and cubilin. Despite the impor...

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Bibliografische Detailangaben

Hauptverfasser:	Katherine E Shipman, Kimberly R Long, Isabella A Cowan, Youssef Rbaibi, Catherine J Baty, Ora A Weisz
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Physiological Society 2022-01-01
Schriftenreihe:	Function
Schlagworte:	kidney endocytosis megalin kinetics
Online-Zugang:	https://journals.physiology.org/doi/10.1093/function/zqac046
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