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Association of germline variants with KRAS-mutation status in colorectal cancer

Abstract Somatic mutations in KRAS are a common driver of colorectal cancer (CRC) and present at different frequencies by race, sex, tumor site, ethnicity, and genetic similarity. Inherited germline variants may influence tumor somatic mutation frequency by altering mutation or DNA repair processes...

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Autori principali: Nijole Pollock Tjader, Johnny Ramroop, Tanish Gandhi, Cara Dauch, Owen Meadows, Patrick Stevens, Rachel Pearlman, Heather Hampel, Elom K. Aglago, Sonja I. Berndt, Amanda Bloomer, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Yin Cao, Andrew T. Chan, Iona Cheng, Niki Dimou, David A. Drew, Amy J. French, Peter Georgeson, Marios Giannakis, Graham G. Giles, Maria Gomez, Stephen B. Gruber, Michael Hoffmeister, Wen-Yi Huang, Meredith A. J. Hullar, Jeroen R. Huyghe, Nicole Loroña, Victor Moreno, Christina C. Newton, Jonathan A. Nowak, Mireia Obón-Santacana, Shuji Ogino, Andrew Pellatt, Anita R. Peoples, Jennifer B. Permuth, Stephanie L. Schmit, Robert E. Schoen, Erin M. Siegel, Robert S. Steinfelder, Wei Sun, Jamie K. Teer, Claire E. Thomas, Quang M. Trinh, Konstantinos Tsilidis, Tomotaka Ugai, Caroline Y. Um, Bethany Van Guelpen, Syed H. Zaidi, Jane Figueiredo, Ulrike Peters, Amanda I. Phipps, Joseph Paul McElroy, Amanda Ewart Toland
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2026-02-01
Serie:Scientific Reports
Soggetti:
Colorectal cancer
KRAS
GWAS
Somatic mutations
Germline variants
Accesso online:https://doi.org/10.1038/s41598-026-39644-8
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