Importance of PERK pathway modulation on colorectal cancer management: a systematic review

Abstract Background The protein kinase RNA-like endoplasmic reticulum kinase (PERK) branch of the Unfolded Protein Response (UPR) plays a complex and context-dependent role in the colorectal cancer (CRC). While some studies indicate that PERK activation suppresses tumor growth by inducing apoptosis...

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Hlavní autoři:	Marzieh Nemati, Sanaz Dastghaib, Zahra Hosseinzadeh, Mina Molayem, Morvarid Siri, Bahareh Ebrahimi, Zohreh Bagheri
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-10-01
Edice:	BMC Cancer
Témata:	Colorectal cancer Endoplasmic reticulum stress Unfolded protein response Protein kinase RNA like endoplasmic reticulum kinase
On-line přístup:	https://doi.org/10.1186/s12885-025-14952-w
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