Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA

ABSTRACT The emergence of oxacillin-susceptible methicillin-resistant Staphylococcus aureus (OS-MRSA) has imposed further challenges to the clinical management of MRSA infections. When exposed to β-lactam antibiotics, these strains can easily acquire reduced β-lactam susceptibility through chromosom...

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Detalhes bibliográficos

Principais autores:	Shinya Watanabe, Chijioke A. Nsofor, Kanate Thitiananpakorn, Xin-Ee Tan, Yoshifumi Aiba, Remi Takenouchi, Kotaro Kiga, Teppei Sasahara, Kazuhiko Miyanaga, Srivani Veeranarayanan, Yuzuki Shimamori, Adeline Yeo Syin Lian, Thuy Minh Nguyen, Huong Minh Nguyen, Ola Alessa, Geoffrey Peterkins Kumwenda, Sarangi Jayathilake, Jastin Edrian Cocuangco Revilleza, Priyanka Baranwal, Yutaro Nishikawa, Feng-Yu Li, Tomofumi Kawaguchi, Sowmiya Sankaranarayanan, Mahmoud Arbaah, Yuancheng Zhang, Maniruzzaman ‌‌, Yi Liu, Hossain Sarah, Junjie Li, Takashi Sugano, Thi My Duyen Ho, Anujin Batbold, Tergel Nayanjin, Longzhu Cui
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology 2024-06-01
coleção:	mBio
Assuntos:	Staphylococcus aureus MRSA antimicrobial resistant beta-lactams OS-MRSA oxacillin
Acesso em linha:	https://journals.asm.org/doi/10.1128/mbio.00339-24
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